White mulberry (Morus alba) has been shown through clinical studies to be an effective natural ingredient for treating various types of skin hyperpigmentation. Some of the key benefits and supporting research include:

• Inhibits tyrosinase enzyme activity: Tyrosinase plays a key role in melanin production. Studies show mulberry extracts significantly decrease tyrosinase activity, reducing melanin synthesis.
• possesses antioxidants: have potent antioxidant effects that protect skin from UV damage and inflammation-induced hyperpigmentation.
• Brightens skin tone: Double-blind clinical trials found mulberry extract serum improved melasma severity via reduction in melanin index, melanocyte count and hyperpigmentation area compared to hydroquinone after 8 weeks.
• Effective for aging spots: In a 12-week randomized study, white mulberry cream was found to be as efficacious as 4% hydroquinone in reducing age spots induced by UVB exposure, with better tolerability.
• Reduces freckles: When used as part of a 4-week protocol including LED light therapy, mulberry gel showed synergistic effects, achieving significant lightening of ephelides (freckles).
• Safe alternative: Unlike hydroquinone, long-term mulberry studies show it causes no cytotoxic or genotoxic effects, irritancy or contact dermatitis. It is a mild yet highly effective option.

Numerous clinical trials provide strong support for white mulberry’s role in skin brightening when treating various pigmentation issues in a gentler way.

The frequency of treatment required depends on your skin pigmentation problem and its severity. However, you can expect visible improvements in 1-2 treatments.